5 Strongest Professional Weed Killers

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Have you tried every household weed killer on the market and still have weeds sprouting in your garden? Perhaps it’s time to upgrade to a professional weed killer. When using a garden sprayer, these are strong concentrated solutions that must be handled with caution. These commercial weed killers are usually systemic, meaning they enter the plant’s entire system and kill the entire plant, including the root.

This is a long article, so if you wish to navigate to a certain section, please do so with our easy clickable Table of Contents below.

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– Best Overall – Gallup Home & Garden Glyphosate Weed Killer

Our analysis of the five most powerful weed killers looks at the weed killers that professionals use to get rid of the toughest perennial weeds and even tree stumps. One of the weed herbicides we tested destroys all plants except grass. We go over the benefits and drawbacks of each product, as well as how it works. Please also read our Buyer’s Guide, which contains important information about the many types of industrial weed killers as well as how to use them safely and effectively.

  1. Gallup Home & Garden Glyphosate Weedkiller
  2. Roundup Super Concentrate Tough Weedkiller
  3. Rootblast Super Concentrated Weed Killer
  4. Resolva Xtra Tough Concentrated Weed Killer
  5. Vitax SBK Brushwood Killer Tough Weedkiller
Table could not be displayed. Table could not be displayed.

Our Top Pick

Gallup Home & Garden Glyphosate Weed Killer

This is a popular glyphosate weed killer that may be purchased by the general population. It can be used in your flower beds as well as around ponds.

For a variety of reasons, this weed killer is one of the most popular professional-strength weed killers for home usage. It’s easy to get and use for home gardeners, and it’s completely safe if you follow the instructions and safety precautions. It destroys the majority of deep-rooted perennial and annual weeds, including mare’s tail, which never seems to go away. All you have to do now is keep youngsters and dogs away from the sprayed area while the liquid dries, which shouldn’t take long. Weeds around your garden pond are fair game for this weed killer because they can be used in aquatic environments. Just make sure that none of the liquid ends up in the pond. Just keep it away from your lawn if you want to use this as a general-purpose commercial-grade weed killer.

Top 5 Strongest Weed Killers Review

1. Gallup Glyphosate Weed Killer


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Glyphosate 360 weedkiller
Glyphosate 360 weed killer

Gallop Glyphosate Weed Killer is by far the most popular professional strength weed killer available for industrial use, as well as the best weed killer available to the general population. While many weed killers have been prohibited over the years, Gallop has managed to evade this fate, at least for the time being, and it is still available for purchase.

Unlike some other weed killers, this systemic weed killer is a foliar-applied translocated herbicide that can be utilised in aquatic regions. Waterways such as rivers and ponds, on the other hand, should be avoided. Use extreme caution and common sense here, as this is a dangerous material that, in incorrect quantities, can harm the environment.

The fact that they applied the weed killer and nothing happened, often for weeks, if not months, is a typical complaint among internet reviewers. The most common reason is that they didn’t apply the solution when the weeds were actively developing; applying the liquid during a dormant phase has no effect because the plant doesn’t absorb it into its roots.

Gallop eliminates most annual and deep-rooted perennial weeds and grasses, which is good news. Mare’s tail is frequently killed as well. However, spraying the mare’s tail with the tops clipped off is recommended. Spraying the weed killer a few times is normally required for it to be successful, and even that is not assured.

Gallop is available in a 1-litre container, a 5-litre container, and a 10-litre container, among other sizes. Although the application rates are adjustable, we recommend starting with the manufacturer’s standard combination of 300ml of concentrate per 10 litres of water (30ml to every 1 litre of water). Always check the instructions on the bottle before combining because this is merely a suggestion and measurements can change.


✔️ Glyphosate Weed Killer that can be used in both aquatic and terrestrial areas, such as around ponds and flower beds.

✔️ Most annual and perennial difficult-to-kill weeds are killed, including mare’s tail, which is famously difficult to eradicate.

✔️ It can be used with either personal or garden sprayers.

✔️ Available in a variety of sizes, with a typical application ratio of 30ml concentrate to 1L water.

✔️ After the solution has dried, anyone, including children and pets, can enter the sprayed area.

✔️ Because it is biodegradable by soil microbes, it is considered to be environmentally friendly.


❌ It kills lawns and any other plants it comes into contact with.

❌ If it gets into waterways like rivers and streams, it can be dangerous.

Our Recommendation

For good reason, Gallop Glyphosate Weed Killer is one of the most popular industrial-strength weed killers. It’s designed for home gardeners and works on the majority of the most noxious weeds found in residential landscaping. It’s simple to use if you follow the directions and observe the safety precautions (and use your common sense).

In our assessment of the strongest weed killers, we named Gallop Glyphosate Weed Killer the Best Pick. We appreciate that it’s easy to find and that, when applied properly and correctly, it gets rid of the majority of the worst weeds in anyone’s garden.

2. Roundup Tough Weed Killer


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Professional weed killer solution to kill Japanese knotweed from your property
Professional weed killer solution to kill weeds from your property

Tougher, deep-rooted weeds like brambles, thistles, and nettles respond well to Roundup Super Concentrate Tough Weedkiller. Most other weed killers are incapable of dealing with this level of growth. This means that Roundup Super Concentrate can be used on both tree stumps and woody bushes.

Because this is a non-selective weed killer, it’s also useful for cleaning areas like undesired plants on paths, roads, and gravel areas. However, unless you want to kill all of your grass, don’t apply this on your lawn.

Roundup Super Concentrate Tough Weedkiller is a systemic weed killer that eliminates tough weeds from the roots up, ensuring that they do not regrow. Be careful that the effects will begin to manifest after 48 hours when the leaves and stem will turn yellow. Don’t be impatient and assume that nothing will happen in the first few days. However, we recommend waiting at least seven days before removing the weeds to verify that the weed killer has reached all of the roots.

The 1 litre super concentrate recipe we tested covers a maximum area of 90m2, so it’ll cover a lot of ground even if it’s a big one. However, other online reviewers claim that in order to get any benefits, they had to apply more than the suggested concentration of solution to water.

Replanting and sowing can commence the day after application if the product is used for light treatment of annual weeds, which is convenient for people with allotments. When the weed killer gets into contact with the soil, it becomes inactive, which is good for the environment. Microorganisms in the soil easily break down the product, allowing it to be replanted.

Allow about seven days for the methodical action to get deep into the roots if applied to areas with dense covers, such as perennial weeds, before digging or cultivating.

A sprayer or a watering can with a fine hose be used to apply the product. If at all possible, we recommend using a sprayer because the diluted weed killer goes a long distance.

For safety reasons and to avoid weed killer transfers to the lawn, keep children and pets out of treated areas until the weed killer has dried on the leaves. After each application, fully rinse the sprayer at least three times.


✔️ Weeds are killed down to the roots with systemic weed killer, and they don’t come back.

✔️ Best for removing tough, woody plants like brambles, nettles, and thistles.

✔️ The yellowing of stems and leaves begins after 48 hours, so don’t be too eager to see the process begin.

✔️ To multitask your garden, lightly spray weeds and then plant the next day in the same location.

✔️ Because it is biodegradable by soil microorganisms, it will not pollute your garden.


❌ Weed killer that isn’t selective.

❌ More than 30mL of concentrate per litre of water is required.

Our Recommendation

Roundup Super Concentrate Tough Weedkiller is one of the Roundup company’s well-known weed killers. This version is for tougher weeds, especially woody plants like brambles, nettles, freshly cut tree stumps, bracken, and perennials with deep roots. One advantage of this weed killer is that it can be planted after 24 hours of lightly spraying the weeds with the solution.

Our pick for the best weed killer for tree stumps and woody plants is Roundup Super Concentrate Tough Weedkiller. This is the weed killer for you if these are the main sorts of weeds that are bothering you.

3. Rootblast Super Concentrated Weed Killer Commercial Strength Glyphosate


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Rootblast Super Concentrated Weed Killer Commercial Strength Glyphosate

Rootblast Super Concentrated Weed Killer is another glyphosate-based commercial weed killer. As a result, it attacks anything it comes across, so keep it away from your lawn and any other plants you want to maintain growing.

However, this weed killer is effective against the common annual and perennial weeds that the other products in our evaluation are also effective against. Docks, nettles, and willowherbs are among the woody plants that benefit from it. This weed killer will also kill your broadleaf and grass weeds.

The fact that this Rootblast weed killer contains a high concentration of the active chemical glyphosate sets it apart from the competition. When diluted at the prescribed ratio, this extra strong concentrate may cover 1,666m2 of weedy landscape for every 1L bottle of concentrate.

This is yet another weed killer that requires patience after application. The yellowing of leaves and stems, which is normally a sign of its progress, may not occur for two to four weeks or even longer. Reapply the product if nothing seems to be happening before this time. Sit back and wait, then get to work on the other gardening projects that have been piling up.


✔️ With commercial strength concentrate, glyphosate weed killer targets deep-rooted perennial and annual weeds, as well as woody weeds.

✔️ Most weed kinds are covered because it is also effective against broadleaf and grassland weeds.

✔️ This weed killer has a highly powerful composition that will kill even the toughest weeds.

✔️ Up to 1,666m2 of weedy areas are covered.


❌ Any yellowing of the leaves can take up to four weeks to appear.

❌ Weed killer that isn’t selective.

Our Recommendation

Rootblast Super Concentrated Weed Killer Commercial Strength Glyphosate is comparable to several of the other products we’ve reviewed in that it successfully kills both woody and broadleaf weeds. The active ingredient, glyphosate, is concentrated in the Rootblast product, allowing it to cover a vast area at the required dilution. If you have a significant area of these weeds that is out of control, this weed killer may be enough to address your problem.

4. Resolva Xtra Tough Concentrate Weed Killer


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Resolva Xtra Tough Concentrate Weed Killer

Another weed killer that works on both annual and deep-rooted perennial weeds is Resolva Xtra Tough Concentrate Weed Killer. The Resolva, on the other hand, specialises in broad-leaved weeds like creeping thistle and annual sow thistle. Because of the IQ technology, which combines the quickness of a contact weedkiller with the deep-root penetration of a systemic weed killer, the manufacturer says that this product has improved killing performance. We’re not convinced that this weed killer is any better than the others on our list. But it works if you use it correctly and at the right time of year.

This weed killer, like our previous two options, is biodegradable and is broken down by soil microbes. This Resolva weed killer is non-selective, non-residual, and systematic. It permeates into any foliage it comes into contact with and travels down into the root system, where the growth enzymes are destroyed. As a result, the weed is killed and future development is prevented, which is why it is so successful.

When the weeds are actively growing, late March to early September is the optimal time to apply this weed killer. Always avoid using the weed killer on lawns and avoid spraying it in locations where you don’t want to harm anything green. Common nettle, cleaves, curled dock, creeping buttercup, scotch thistle, and a variety of other weeds are also targeted by this weed killer. It’s important to remember that some stubborn weeds may not show evidence of improvement for up to four weeks following application, so don’t assume nothing is happening.

The Resolva Xtra Tough Concentrate Weed Killer is available in several sizes. The ergonomically designed 1-litre bottle we tested has finger grips on one side to ensure you have a strong grip and don’t drop it. This weed killer is cost-effective and comes in a 200ml bottle or six 100ml sachets. The larger bottles, like with other beverages, provide better value for money.


✔️ For improved results, a systematic weed killer procedure was combined with a contact weed killer procedure.

✔️ Say goodbye to creeping thistle and annual sow thistle, as this herb is particularly effective against broad-leaved weeds.

✔️ Excellent for eradicating all weeds in a big region infested with them.


❌ Because it is non-selective, it will kill any foliage it comes into contact with.

❌ It could take up to four weeks for any change to be visible.

Our Recommendation

Most household weeds are killed with Resolva Xtra Tough Concentrate Weed Killer, but it’s especially good for getting rid of an area overrun with undesired weeds. It specialises in broad-leaved weeds including docks, thistles, nettles, creeping buttercup, dandelion, and other invasive species with deep roots.

This weed killer might just do the trick if your weeds have a lot of broad-leaved weeds or if you have a large weed patch at the bottom of your garden.

5. Vitax SBK Brushwood Killer Tough Weed Killer


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Vitax SBK Brushwood Killer Tough Weedkiller

Vitax SBK Brushwood Tough Weedkiller appears to be identical to Roundup Super Concentrate Tough Weedkiller, which we previously examined. Woody weeds including brambles, thistles, nettles, dock, ivy, hardwood saplings, and tree stumps are no match for them. However, there is one significant distinction: Vitax SBK Brushwood Tough Weedkiller does not affect the grass. That’s right, this stuff isn’t going to destroy your grass.

Because the Vitax SNX product contains triclopyr rather than glyphosate, this is the case. Triclopyr is effective against woody plants and broadleaf weeds but not grass. As a result, Vitax is the only weed killer on our list that you can use without fear of destroying your lawn. If you have a lot of weeds on your lawn, you may use it there as well; it’s especially wonderful for violets. This is still a systemic weed killer that reaches the plant’s roots and kills it.

Because Vitax has a residual impact, anticipate it to persist in the soil for a few weeks after application. This prevents you from immediately planting in the region. The active chemical is biodegradable and has a half-life of 60 days, though it can last up to 90 days in dead plants. As a result, you must wait at least six weeks before re-cultivating or planting after using this weed killer.

When the soil is moist, the best time to apply Vitax on hardwood saplings and difficult weeds is from May through October. Woody weeds respond best to treatment between June and August, whereas tree stumps respond best between autumn and winter when the sap is receding downwards.

We do not advocate applying this on newly-turfed lawns, even if it does not harm them. Finally, this weed killer is reasonably priced and is available in 125ml, 250ml, 500ml, and 1-litre concentrate bottles.


✔️ Brambles, nettles, and freshly cut tree stumps will all succumb to this selective triclopyr weed killer designed specifically for brushwood and woody plants.

✔️ It’s as efficient against broadleaf weeds, especially the invasive Creeping Charlie.

✔️ Grass is unaffected, so your lawn is protected from inadvertent spraying or when you use it to get rid of weeds.

✔️ Brush control is effective, allowing you to wipe up your straggly bushes.


❌ It takes six weeks from application to replanting.

Our Recommendation

Vitax SBK Brushwood Tough Weedkiller provides what you want while staying away from what you don’t. It works well on broadleaf weeds as well as woody weeds and tree stumps. If you wish to clear the brush from the concealed areas at the end of your garden, this method works well. However, it has no effect on your lawn. It’s safe to use this close to the lawn. You can even use it to get rid of weeds on your grass. One disadvantage is the length of time you must wait (six weeks) before applying the solution and replanting.

This weed killer could get rid of most of the numerous varieties of weeds you have, wherever they are in your garden if you plan wisely.

Buyer’s Guide

Chemicals Types

Professional gardeners use the same weed killers to treat common areas around buildings, huge areas of beds and borders, as well as paths and parking lots. All of the professional weed killers we’ve looked at are concentrated. This implies you’ll need to dilute them by mixing a particular amount of concentrate with a particular amount of water (typically 1 litre). Each weed killer may have a different concentrate-to-water ratio, so read the instructions on the bottle carefully.


Glyphosate is used in the majority of commercial weed killers. Because each brand may include a different concentration of this substance, always read the bottle label to see what’s printed on it. The higher the glyphosate concentration, the greater the concentration. This chemical can be found in home weed killers, though at much lower concentrations.

Weed pesticides containing glyphosate kill in a systemic manner. This means that the liquid enters the plant’s leaves and travels down the entire internal system of the plant, all the way to the roots. The poison is glyphosate, which kills every part of the plant from the inside out, from the leaves to the root tips.

Weed killers containing glyphosate are biodegradable. When the liquid comes into contact with the soil, it becomes inactive, and the microorganisms in the soil decompose it into natural elements, rendering it harmless.

These weed killers work best on both broadleaf and grass weeds.


Commercial-grade weed killers based on triclopyr are selective, meaning they kill almost everything except grass. One of these products, the Vitax SBK Weedkiller, is included for those home gardeners whose otherwise lush and magazine-worthy lawns are plagued by weeds.


Making up the correct concentration

When using your weed killer for the first time, check the instructions on the bottle or packaging for the proper dilution ratio to use. After seeing the outcomes of your first applications, you may choose to adjust the ratio to a more concentrated or dilute solution at a later time.

How to safely mix weed killer

Follow the directions for mixing the concentrate and water, which are normally in a watering can or jug set aside for this purpose. Even if you carefully clean it out after mixing everything, some solution may remain and end up wherever you don’t want it. Also, protect your skin by wearing gloves, eye protection, and other protective equipment.

How to Get Started

You can use a sprayer or a watering can with a fine nozzle to apply your weed-killer solution. However, we always advocate using the sprayer because it uniformly and delicately distributes the solution, allowing the liquid to travel further. Also, even after you’ve completely rinsed the sprayer three times at the end of the application operation, don’t use it for anything else. However, before using, read the instructions on the container carefully and only use as advised.

For your own protection, always wear protective gloves, masks, and goggles. Also, make sure no spray gets into your garden pond or any adjacent stream or river. It has the potential to infect them, as well as the fish and aquatic plants that live there.

When should you use weed killer?

Always read the directions, once again. However, commercial-grade weed killers should be applied during the active growing season of the weed, which is usually between March and September. Because the weed killer works systemically and must pass through the entire system of the plant, it must be active and not dormant, as it is in late fall or winter.

NB: Don’t spray on a windy day or if rain is forecast within the next six to eight hours.


I’ve tried several weed killers and failed to get rid of the weed. What should I do?

Many people wonder how to get rid of the weed. The standard response is to use a glyphosate-based weed killer and wait. Any of the glyphosate-based products we reviewed will suffice. Just be prepared to re-spray if the weed reappears, as it can take several years to entirely eradicate it. When treating a big area with this weed, professional businesses typically treat it for five years, so a single spray will have little effect. Single sprays of weed killers don’t always work for some weeds; you’ll have to stick with them and keep re-treating them.

Should I reapply the weed killer if nothing happens?

Are you certain that nothing is going on? During our investigation for this review, the most common complaint we heard was that the weed killer didn’t work. And we discovered this for each and every weed pesticide. If you study the instructions/information for your weed killer, you’ll notice that indicators of decay might appear anywhere from two days to a few days or even weeks.

Some weed killers don’t start working until several weeks or even months after they’ve been applied. The poison may be functioning on the plant’s internal system, finding its way down to the roots and out to the tips of the leaves, even while the weeds’ leaves and stems aren’t browning. Simply wait a little longer and see what happens.

If you’ve waited and nothing has happened, there could be a number of reasons why the weed killer hasn’t worked. Did you use it during the plant’s active season? Was the solution sufficiently concentrated? Is it possible that it rained within eight hours after application, washing the weed killer away? If feasible, fix the problem (unless the weed is dormant) and reapply the treatment.

Final Conclusion

Although there are many weed killers on the market, we only recommend five of them. Gallup Glyphosate Weedkiller is our top recommendation, and it’s definitely the most effective weed killer available to the common person.

Professional-grade weed killers, maybe your next move if domestic weed killers haven’t made a dent in some of your toughest weeds and you’ve given it enough thought. The majority of the products we test are glyphosate-based, which means they kill things other than weeds, like your lawn. Only one triclopyr-based weed pesticide is safe for your grass while killing practically everything else. It isn’t difficult to select the best commercial-strength weed killer for your needs, but it does necessitate some thought.

Gallup Glyphosate Weedkiller is our top pick for the most powerful weed killers. This is one of the most powerful products for the home grower. It kills a variety of weeds and will kill your lawn if you get any on your lawn.

Our Best Weed Killer for woody weeds and tree stumps is Roundup Super Concentrate Tough Weedkiller. It’s based on glyphosate as well, but it’s particularly powerful against brambles, nettles, and dandelions. But, once again, watch out for your lawn.

We have to mention our lone option that isn’t harmful to your lawn but destroys almost everything else. The Vitax SBK Brushwood Tough Weedkiller is gentle on your lawn but powerful enough to eradicate huge brushwood areas.

If you determine that an industrial-strength weed killer isn’t what you need, check out our list of the Best Weed Killers for Driveways. If you have a lot of tiny ones roaming about in your garden, check out our post on the Best Pet-Friendly Weed Killer.